prophylactic anti-emetic effect of dexamethasone and metoclopramide on the nausea and vomiting induced by laparoscopic cholecystectomy: a randomized, double blind, placebo-controlled trial

Authors

ali reza khalaj department of surgery, shahed university, tehran, ir iran

seyed rohollah miri department of surgery, tehran university of medical sciences, tehran, ir iran , +98-2122323252; department of surgery, tehran university of medical sciences, tehran, ir iran , +98-2122323252

mojdeh porlashkari department of pathology, tehran university of medical sciences, tehran, ir iran

amin mohammadi tehran university of medical sciences, tehran, ir iran

abstract

conclusions dexamethasone 8mg is a better anti-emetic agent than metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy. objectives this study evaluates the prophylactic anti-emetic effect of dexamethasone in comparison with metoclopramide and placebo for the prevention of post-operative nausea and vomiting in patients undergoing elective laparoscopic cholecystectomy. patients and methods in mostafa khomeini hospital, a teaching hospital of shahed university, tehran, iran, a randomized, double-blind and placebo-controlled study on 161 patients undergoing general anesthesia for elective laparoscopic cholecystectomy was run.one hundred sixty one patients (124 females and 37 males) requiring general anesthesia for laparoscopic cholecystectomy were studied. the dexamethasone group (n = 53) received dexamethasone 8mg iv, the metoclopramide group (n = 55) received metoclopramide 10mg iv and the placebo group (n = 53) received 2ml saline iv at the induction of anesthesia. results in the current study, 26.4 %, 32.7 % and 52.8 % of patients reported vomiting in the dexamethasone, metoclopramide and placebo group (p < 0.001), respectively. the total incidence of nausea and vomiting also reduced to 30.2 % with dexamethasone in comparison with 49.1 % in metoclopramide group and 58.5 % in placebo group. (p < 0.001) background postoperative nausea and vomiting (ponv) is an unpleasant, distressing and frequent adverse effect after general anesthesia and surgery which has a high incidence in patients undergoing laparoscopic cholecystectomy. while none of the currently available antiemetic drugs are fully effective in all patients, it has been reported that dexamethasone is effective against emesis in patients undergoing general anesthesia.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial

Introduction: Nausea and vomiting are conditions that could occur after anesthesia and lead to reduced activity and surgery dissatisfaction. Therefore, according to its importance, this study was accomplished in order to compere the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy. Materials and Methods: This study was a double-blind...

full text

Effect of oral ginger on prevention of nausea and vomiting after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial

Background Postoperative nausea and vomiting (PONV) are among the most frequent complications following laparoscopic cholecystectomy. Recently, some studies have shown ginger, as an herbal medicine, to be effective and safe in PONV prevention; however, there is no evidence of its efficacy in the Iranian population. Objective The aim of this study was to determine the effect of oral ginger on ...

full text

The Effect of Inhalation of Ginger Extract on Postoperative Nausea, Retching and Vomiting after Laparoscopic Cholecystectomy: A Randomized Clinical Trial

Background & objectives: Nausea, retching and vomiting are common complications after surgery. Despite the medical treatment, patients still suffer from these complications. The use of non-pharmacological methods can reduce these complications. Therefore, the aim of this study was to determine the effect of inhalation of ginger extract on postoperative nausea, retching and vomiting after laparo...

full text

effect of prophylactic gabapentin on post operative nausea and vomiting after laparoscopic cholecystectomy: a randomized controlled trial

background: postoperative nausea and vomiting (ponv) is a frequent and unpleasant adverse event associated with surgery. the reported incidence of ponv after laparoscopic cholecystectomy (lc) is quite high. despite the use of different drugs to prevent or relieve ponv, it continues to be undermanaged. recently, studies have been undertaken to determine if gabapentin can be useful for the prevent...

full text

Prevention of postoperative nausea and vomiting by metoclopramide combined with dexamethasone: randomised double blind multicentre trial.

OBJECTIVES To determine whether 10 mg, 25 mg, or 50 mg metoclopramide combined with 8 mg dexamethasone, given intraoperatively, is more effective in preventing postoperative nausea and vomiting than 8 mg dexamethasone alone, and to assess benefit in relation to adverse drug reactions. DESIGN Four-armed, parallel group, double blind, randomised controlled clinical trial. SETTING Four clinics...

full text

Efficacy of metoclopramide and dexamethasone for postoperative nausea and vomiting: a double-blind clinical trial.

Postoperative nausea and vomiting are common complications of anaestnesia. This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo (saline), metoclopramide (10 mg), dexamethasone (8 mg) or the 2 drugs combined. The incidence of nausea in the recovery room was 44% ...

full text

My Resources

Save resource for easier access later


Journal title:
journal of minimally invasive surgical sciences

جلد ۲، شماره ۳، صفحات ۱۸-۲۲

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023